Life Tech Medical device

Method for removing bacterial films

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The therapeutic effectiveness of antibiotics diminishes as bacteria acquire antimicrobial resistance.
Biofilms are one of the main causes of antibiotic treatment failure.
Antibacterial treatment associated with biofilm often requires physical procedures or the administration of high doses of antibiotics to hosts, which in turn can lead to selective resistance and more serious adverse effects in treated patients.
There is an urgent need to destroy biofilms in order to combat antibiotic resistance.

Competitive advantages

  • Destruction of biofilm
  • Sensitisation of bacteria to existing antibiotics
  • Non-toxic/harmless to mammalian cells
  • Wide range of potential applications

Applications

  • Disinfection of reusable medical devices (endoscopes, catheters) and implantable medical devices (orthopaedic implants, valves)
  • Tissue treatment (chronic wounds, ulcers, dental implants, endocarditis, osteoarticular biofilms)

Intellectual property

  • Patent

Development stage

Laboratory validation of the technology

Laboratory

IPBS

Description

Anisotropic superparamagnetic iron oxide nanochains

  • activated by a low-frequency, low-intensity rotating magnetic field
  • mechanical destructuring of the biofilm allowing the antibiotic to reach the bacteria
    biocompatible and non-toxic to mammalian cells

Technical specifications

  • Composed of an iron oxide core and a silica shell, functionalized with -COOH groups
  • Size: diameter 150 nm, length up to 2 μm, can form transient beams when exposed to a weak magnetic field
  • Zeta potential: -31 mV at pH 7.4