Life Tech Therapeutics

Peptide reinforcing the properties of the epidermis

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The barrier function of the epidermis can be altered in various environmental conditions or in relation to the patient's condition. Active ingredients capable of promoting the skin’s regeneration processes or the endogenous synthesis of constituents of the natural hydration factor can counterbalance these alterations.

COMPETITIVE ADVANTAGES

  • Originality of the sequence

  • Specificity in tissue expression demonstrating its functionality

APPLICATIONS

  • Reinforcing the barrier function of the epidermis

  • Treatment of signs of dryness or skin ageing

  • Prevention/treatment of skin trophic disorders and/or following wound healing

  • Treatment of xerosis, ichthyosis, psoriasis, keratoses

INTELLECTUAL PROPERTY

  • Patent

DEVELOPMENT STAGES

Experimental proof of concept

LABORATORY

pictrogramme d'illustration
  • UDEAR

Description

  • Peptide sequences (5 aa to 15 aa) derived from the LCE6A polypeptide (80 aa) belonging to the “Late Cornified Envelope” (LCE) family
  • Originality: little homology with the other five groups derived from the LCE family
  • Function: expression of the LCE6A gene is strongly induced in the fraction enriched in granular keratinocytes
  • Specificity: expression of the LCE6A gene in the epidermis and not in 17 other healthy tissues or organs
  • In vitro evidence of binding to transglutaminases 2 and 3
Crédit photo : TTT-UDEAr. Les peptides d'intérêt se lient aux transglutaminases dans le stratum corneum.

Technical specifications

  • In vitro evidence of binding to transglutaminases 2 & 3
  • Short LCE6A peptides can be cross-linked to cornified envelopes in vitro & ex vivo
  • Cornified envelopes cross-linked with LCE6A peptides are more resistant to mechanical stress