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Vaccine platform based on OMV (Outer Membrane Vesicles)
COMPETITIVE ADVANTAGES
- Ability to adapt OMVs to different pathogens
- Reduced production costs
- Quantity and ease of production/purification
APPLICATIONS
- Animal health
INTELLECTUAL PROPERTY
- Patent
DEVELOPMENT STAGE
Laboratory validation of the technology
LABORATORY
- IRSD
Description
Use of the HlyF protein in gram-positive bacteria for the massive production/secretion of OMVs
Cloning of specific antigens for expression in OMVs. Proof of concept in animals: immunisation of a cohort of chickens against avian colibacillosis (no effect on animal growth, strong immunisation of animals against infection).
Technical specifications
- Possibility of combining several antigens in OMVs
- Possibility of expressing any type of antigen, antigen fragments
- Expression of antigens on the surface of OMVs or in the lumen of OMVs (response tailored to each pathogen)